Antibody-conjugated drugs (antibody-drug conjugate,ADC) combine high specificity of monoclonal antibody drugs and high activity of small molecule cytotoxic agents to improve the targeting of tumor drugs and reduce toxic side effects.Compared to conventional complete or partially humanized antibodies...
Putting cell surface antigens usually involves normal growth or proliferation processes of cells, generally cell surface proteins, glycoproteins, or polypeptides, etc.Ideal antigen targets should be substantially specifically expressed on the target cell surface, with limited or not expression on th...
Other requirements of ADC for connected toxins include: 1, sufficient water solubility, and stability in serum, because ADC may circulate in the body for days; 2, there must be functional groups that can be used to associate to Linker; 3, must be insensitive to enzymatic degradation of lysosomes; 4,...
The linkers currently used are mainly divided into two categories according to different mechanisms, the first cleavable linker and the second non-cleavable linkers.There are three different types of release mechanisms for cleavable linkers: 1. Lysosomal protease-sensitive linkers.Using lysosomal pr...
