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Selection of targets of conjugated antibodies

作者:超级管理员发布时间:2021-10-27 08:58:49

Putting cell surface antigens usually involves normal growth or proliferation processes of cells, generally cell surface proteins, glycoproteins, or polypeptides, etc.Ideal antigen targets

should be substantially specifically expressed on the target cell surface, with limited or not expression on the normal tissue or cell surface, along with a certain endocytic rate as well as an

appropriate endocytic transport pathway.The current ADCs under development cover almost all corroborated targets, and the target determination also basically determines the adaptive

indication of ADCs.In terms of different solid and hematological tumors, the following targets have been or are being evaluated by major research institutions whether they are potential

targets for appropriate ADC drugs.